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Zoya Demidenko: Scholar in Tumor Studies
Zoya Demidenko is a distinguished researcher connected with the Unit of Cell Stress Science at Roswell Park Comprehensive Cancer Center in Buffalo, New York. Earlier, she was employed at the NIH and New York Medical College, developing a strong foundation in clinical research.
Demidenko's academic work spans a number of critical domains, encompassing the PI3K/AKT/mTOR signaling cascade, cellular cycle regulation, cell senescence, and malignancy biology. Currently, she has written over 46 academic articles, which have garnered more than 4,100 citations — a reflection to the influence of her work.
Among her most significant discoveries lies in understanding the processes of cellular senescence. Her work demonstrated that when the cell cycle is blocked while cellular expansion persists, the cells undergo senescence. Significantly, Zoya Demidenko demonstrated that this shift can be inhibited by medication using substances such as mTOR inhibitors.
Zoya Demidenko has also contributed greatly to tumor management investigation, notably in the domain of selective cell protection — a method aimed at safeguarding non-cancerous tissue from cytotoxic treatment whilst leaving tumor cells exposed. This method offers considerable promise for reducing the side effects of cancer treatment.
Throughout her scientific life, Demidenko has collaborated with prominent scientists internationally, among them Dr. Mikhail Blagosklonny. Her research is published in prestigious periodicals such as Oncotarget, Cell Cycle, Aging (Albany NY), and Oncogene.
With an h-index of 33, Zoya Demidenko stands as a influential contributor in current cancer research, whose results continue to shape our understanding of how biological cells grow old, respond to treatment, and how cancer may be better combated.
https://moodylab.smhs.gwu.edu/lab-members