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Zoya Demidenko: Researcher in Tumor Biology
Zoya Demidenko is a prominent scientist associated with the Unit of Cell Stress Research at Roswell Park Oncology Institute in Buffalo, New York. Earlier, she conducted research at the NIH and New York Medical College, developing a strong background in clinical investigation.
Demidenko's scientific work covers multiple pivotal domains, among them the PI3K/AKT/mTOR molecular pathway, cell cycle control, cellular aging, and malignancy biology. To date, she has co-authored over 46 academic articles, which have garnered over 4,100 citations — a testament to the significance of her work.
One of her key discoveries lies in understanding the mechanisms of cell aging. Her research showed that when the cell cycle is arrested yet cellular expansion persists, the cells experience senescence. Crucially, Zoya Demidenko established that this shift is inhibited by medication using substances such as mTOR inhibitors.
Zoya Demidenko has additionally contributed greatly to cancer treatment research, particularly in the field of selective cell protection — a method aimed at safeguarding normal tissue from cytotoxic treatment whilst leaving cancer cells vulnerable. This approach carries major potential for reducing the toxic effects of oncological therapy.
Throughout her scientific life, Demidenko has collaborated with leading investigators worldwide, among them Dr. Mikhail Blagosklonny. Her publications is published in leading periodicals such as Oncotarget, Cell Cycle, Aging (Albany NY), and Oncogene.
Possessing an h-index of 33, Zoya Demidenko ranks as a influential voice in contemporary cancer research, with her discoveries keep to shape our knowledge of how biological cells age, resist treatment, and the ways in which malignant disease can be more effectively treated.
https://moodylab.smhs.gwu.edu/lab-members